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Kanzius Laboratory Group is First in the World to Reach the Nucleus of Cancer Cells with Nanoparticles

January 26, 2012
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(ERIE, PA) – January 26, 2012 — Kanzius Cancer Research Foundation¬†announces research conducted in the Kanzius/Curley Lab at The University of Texas M.D. Anderson Cancer Center has been published in the January 2012 issue of Biomaterials journal. The manuscript illustrates how Drs. Steven A. Curley, Mustafa Raoof, Yuri Mackeyev, Mathew A. Cheney and Lon J. Wilson’s studies make our research the first in the world to prove that they can get carbon nanoparticles into the nucleus of cancer cells. They were able move nanoparticles into the fluid environment around the nucleus (cytoplasm) in prior studies, but never before could they reach the actual nucleus where the DNA of cells is located. Now that they have, it will open the door for the Kanzius radiofrequency field treatment to succeed.

Essentially, DNA in the nucleus is particularly sensitive to heat and if it is damaged and destroyed with the Kanzius radiofrequency field treatment, the cancer cells will die rapidly.  The researchers are now working to use the carbon nanoparticles to target cancer cells in animals with pancreatic or liver cancer.

Dr. Curley, Chief of Gastrointestinal Tumor Surgery and Program Director of Multidisciplinary Gastrointestinal Cancer Care at the University of Texas M.D. Anderson Cancer Center, noted, “The carbon nanoparticles are fascinating because they are the smallest particles we have used.¬† It is also possible to attach chemotherapy drugs or other agents to the carbon nanoparticles and have the nanoparticles carry these into the nucleus with them.” Curley also stated that he believes “this will further enhance treatment in the Kanzius radiofrequency field to produce heating of the cancer cell and ultimately, cancer cell death.”

“Every day, our team at the Kanzius Cancer Research Foundation works to help fund this incredible research,” said Mark Neidig, Executive Director of KCRF. “These recent findings bring us another step closer to our goal of producing an effective, noninvasive cancer treatment that doesn’t have the harsh side effects associated with current treatments like chemotherapy and radiation.”

This entire manuscript “Internalization of C60 fullerenes into cancer cells with accumulation in the nucleus via the nuclear pore complex” can be found in the January 2012 issue of Biomaterials or at www.Kanzius.org/Manscripts2012.01.

Mark A. Neidig, Sr.

Executive Director

Kanzius Cancer Research Foundation

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